In a storyline about morning show newsanchor Robin's new coworker they mentioned that he is a "veteran of no fewer than 38 local morning shows" and showed shots of their sets in Seattle, Beaverton, and my hometown of Cedar Rapids.
I'm not sure how many people noticed this but I'm sure anyone else from Iowa, like myself, gave a chuckle. It was only on screen for a few seconds but since I had it on DVR, I immediately backed it up and looked at the image behind the anchor desk and noticed that it looked more like Des Moines than Cedar Rapids.
Consulting some quick images on Flickr (see below) it looks like it's definitely Des Moines with the signature 801 Grand missing from the center of the image. The tall buildings on the "Get Up Cedar Rapids" set appear to be (L to R) EMC Insurance, the Financial Center on Walnut, the Ruan Center, and The Plaza. Feel free to read up on them here: Des Moines' Tallest Buildings. Several of the residential loft buildings are also in the image.
One on hand, it's cool that the HIMYM production staff went so far as pull a local skyline image for use on the show. On the other hand, it's interesting that they felt Des Moines worked better than Cedar Rapids (which, as you can see below, does have it's own skyline).